中医药调控血管内皮生长因子信号通路治疗股骨头坏死的研究进展*

作者：李 慧1，陈 欣2，齐 伟2，路 虎1，刘伟闯1，刘明昌1，刘建军2

单位：1.甘肃中医药大学，甘肃 兰州 730000； 2.甘肃中医药大学附属医院，甘肃 兰州 730002

引用：引用：李慧，陈欣，齐伟，路虎，刘伟闯，刘明昌，刘建军.中医药调控血管内皮生长因子信号通路治疗股骨头坏死的研究进展[J].中医药导报,2026,32(1):165-169,177.

DOI：10.13862/j.cn43-1446/r.2026.01.028

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摘要：归纳总结中医药调控血管内皮生长因子（VEGF）信号通路治疗股骨头坏死的研究进展。中药活性成分（如栀子苷、淫羊藿苷）、复方制剂（如生骨再造丸、补肾活血胶囊）及联合疗法（如针灸、富血小板血浆联合中药）可通过激活缺氧诱导因子-1α（HIF-1α）/VEGF、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路促进血管生成与骨修复、抑制炎症与氧化应激、增强成骨-血管偶联、改善骨代谢平衡，治疗股骨头坏死。

关键词：股骨头坏死；中医药；血管内皮生长因子；血管生成；综述

Abstract：

This article summarizes research progress on TCM regulating the vascular endothelial growth factor (VEGF) signaling pathway to treat osteonecrosis of the femoral head (ONFH). TCM active ingredients (e.g., geniposide, icariin), compound preparations [e.g., Shenggu Zaizao Pill (生骨再造丸), Bushen Huoxue Capsule (补肾活血胶囊)], and combined therapies (e.g., acupuncture, platelet-rich plasma combined with TCM) can promote angiogenesis and bone repair, inhibit inflammation and oxidative stress, enhance osteogenic-angiogenic coupling, and improve bone metabolic balance in the treatment of ONFH by activating signaling pathways such as HIF-1α/VEGF and PI3K/Akt.

Key words：osteonecrosis of the femoral head; traditional Chinese medicine; vascular endothelial growth factor; angiogenesis; review

发布时间：2026-01-30

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