中医药调节肠神经递质相关通路治疗慢性传输型便秘的研究进展*

作者：李博南，何 永

单位：山东中医药大学，山东 济南 250300

引用：引用：李博南，何永.中医药调节肠神经递质相关通路治疗慢性传输型便秘的研究进展[J].中医药导报,2025,31(10):102-107.

DOI：10.13862/j.cn43-1446/r.2025.10.018

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摘要：通过文献阅读与整理，阐述中医药调节肠神经递质相关通路治疗慢性传输型便秘（STC）的研究进展。慢性传输型便秘中医病机与人体外感邪气、饮食不节、情志失调、年老久病导致肺脾肝肾功能失常，气血津液运化失常而致大肠传导功能失调有关。肠神经递质血管活性肽、P物质、5-羟色胺、一氧化氮，相关的水通道蛋白及Cajal间质细胞介导的SCF/c-kit、TGF-β/Smad、PI3K/Akt、MAPKs、PLC-γ、miR-34c-5p等信号通路，均与STC的发生相关。单味中药、中药汤剂、中成药、中医综合疗法可调节肠神经递质相关AQPs、TNF、AC/cAMP/PKA、CaM-MLCK、SCF/c-kit、MAPK/NF-κB、NO-cGMP-PKG、GRP78/CHOP、PLC-γ、PI3K/Akt等信号通路，从而治疗STC。

关键词：慢性传输型便秘；中医药；肠神经递质；综述

Abstract：

Through literature review and synthesis, this article elaborates on the research progress regarding TCM regulation of intestinal neurotransmitter-related pathways in treating slow transit constipation (STC). The TCM pathogenesis of STC is related to dysfunction of the lung, spleen, liver, and kidney caused by external pathogens, improper diet, emotional disorders, aging, or chronic illness, leading to abnormal transportation and transformation of Qi, Blood, and Body Fluids, and consequently impaired conveyance function of the large intestine. Intestinal neurotransmitters (such as vasoactive intestinal peptide, substance P, 5-HT and nitric oxide), related aquaporins, and signaling pathways mediated by interstitial cells of Cajal (e.g., SCF/c-kit, TGF-β/Smad, PI3K/Akt, MAPKs, PLC-γ, miR-34c-5p) are associated with the occurrence of STC. Single herbs, herbal decoctions, Chinese patent medicines, and comprehensive TCM therapies can regulate intestinal neurotransmitter-related signaling pathways (e.g., AQPs, TNF, AC/cAMP/PKA, CaM-MLCK, SCF/c-kit, MAPK/NF-κB, NO-cGMP-PKG, GRP78/CHOP, PLC-γ, PI3K/Akt), thereby treating STC.

Key words：slow transit constipation; traditional Chinese medicine; intestinal neurotransmitters; signaling pathways; review

发布时间：2026-01-08

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