基于离子通道机制探究中药活性成分干预心律失常的研究进展*

作者：王红丹1，杨 楠1，毕珺辉1，马育轩1，修 俭2

单位：1.黑龙江中医药大学，黑龙江 哈尔滨 150040；2.肇庆市第一人民医院，广东 肇庆 526000

引用：引用：王红丹，杨楠，毕珺辉，马育轩，修俭.基于离子通道机制探究中药活性成分干预心律失常的研究进展[J].中医药导报,2025,31(10):97-101.

DOI：10.13862/j.cn43-1446/r.2025.10.017

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摘要：

系统综述中药活性成分基于离子通道机制干预心律失常的研究进展，重点探讨钠、钾、钙、氯离子通道的功能异常与心律失常的关系，并阐明中药活性成分（如葛根素、人参皂苷、苦参碱等）通过特异性调节这些离子通道发挥治疗作用的分子机制。结合中医理论，提出“气血阴阳失调”“痰瘀互结”等病机与离子通道异常的关联性，揭示中药“辨证论治”与微观靶点调控的结合潜力。未来研究应进一步明确中药活性成分的作用靶点，并探索中西医结合精准治疗策略，为抗心律失常药物的研发提供新思路。

关键词：心律失常；钠离子通道；钾离子通道；钙离子通道；氯离子通道；中药活性成分；综述

Abstract：

This article systematically reviews the research progress on the intervention of active ingredients of Traditional Chinese Medicine (TCM) in arrhythmia based on ion channel mechanisms. It focuses on the relationship between dysfunction of sodium, potassium, calcium, and chloride ion channels and arrhythmia, and elucidates the molecular mechanisms by which TCM active ingredients (such as puerarin, ginsenosides, matrine, etc.) exert therapeutic effects through specific regulation of these ion channels. Integrating TCM theory, it proposes the potential correlation between pathogenesis patterns like "imbalance of Qi, Blood, Yin, and Yang" or "intermingled Phlegm and Blood Stasis" and ion channel abnormalities, revealing the combinatory potential of TCM "syndrome differentiation and treatment" with microscopic target regulation. Future research should further clarify the targets of TCM active ingredients and explore precision treatment strategies integrating Chinese and Western medicine, providing new insights for the development of anti-arrhythmic drugs.

Key words：arrhythmia; sodium ion channel; potassium ion channel; calcium ion channel; chloride ion channel; active ingredients of traditional Chinese medicine; review

发布时间：2026-01-08

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