鸭嘴花碱的结构修饰与生物活性研究进展*

作者：李美玲1，李 伟1，孙 赟2，张永新1,3，王成名1，陆 珊1，刘 丽1,3

单位：1.个旧市中医医院/个旧市中西医结合医院，云南 个旧 661000； 2.云南中医药大学，云南 昆明 650500； 3.个旧市人民医院，云南 个旧 661000

引用：引用：李美玲，李伟，孙赟，张永新，王成名，陆珊，刘丽.鸭嘴花碱的结构修饰与生物活性研究进展[J].中医药导报,2025,31(10):73-79.

DOI：10.13862/j.cn43-1446/r.2025.10.013

PDF： 下载PDF

摘要：鸭嘴花碱（vasicine）是从民族药鸭嘴花及骆驼蓬属植物中分离得到的一种吡咯并[2,1-b]喹唑啉类生物碱，具有抗炎、抗肿瘤、镇咳、心血管保护、抗菌等多种生物活性。鸭嘴花碱分子中含有喹唑啉单元，活性位点较多且毒性较低，在新药研发方面具有较大的潜力。目前对鸭嘴花碱的研究主要集中在生物活性方面，对其进行结构修饰的研究较少。本研究对鸭嘴花碱的结构修饰与生物活性进行综述，为从天然产生的喹唑啉生物碱中发现更好的新药提供新的线索和可能性，以期为民族药植物资源的开发和利用提供科学依据和技术支持。

关键词：鸭嘴花；鸭嘴花碱；结构修饰；生物活性；综述

Abstract：

Vasicine is a pyrrolo [2,1-b] quinazoline alkaloid isolated from leaves and stems of Adhatoda vasica and Plants from genus Peganum, which has various biological activities such as anti-inflammatory, anti-tumor, antitussive, cardiovascular protection, and antibacterial. Vasicine molecules contain quinazoline units, with many active sites and low toxicity. It has great potential in the development of new drugs. At present, research on vasicine mainly focuses on its biological activity, while there is relatively little research on its structural modification. In present work, we summarized the progress in the research of the structural modification and biological activity of vasicine, providing new clues and possibilities for discovering better new drugs from naturally produced quinazoline alkaloids, and providing scientific basis and technical support for the development and utilization of ethnic minority medicinal plant resources.

Key words：adhatoda vasica nees; vasicine; structural modification; biological activity; review

发布时间：2026-01-08

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