中药复方治疗肺纤维化的用药规律*
作者：杨 浩1,2，贺晓萱1,2，苗心宇1,2，王海峰1,2,3
单位：1.河南中医药大学第一附属医院国家区域中医（肺病）诊疗中心，河南 郑州 450000； 2.河南中医药大学第一临床医学院，河南 郑州 450000； 3.呼吸疾病中医药防治省部共建协同创新中心，河南 郑州 450000
引用：引用：杨浩，贺晓萱，苗心宇，王海峰.中药复方治疗肺纤维化的用药规律[J].中医药导报,2025,31(9):157-163.
DOI：10.13862/j.cn43-1446/r.2025.09.027
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摘要：目的：探讨中药复方治疗肺纤维化的用药规律。方法：收集近10年中国知网（CNKI）、万方数据知识服务平台（Wanfang Data）、维普中文期刊服务平台（CSTJ）、中国生物医学文献服务系统（SinoMed）收录的中医药治疗肺纤维化的临床研究文献，筛选后，使用Microsoft Excel 2021提取资料并建立数据库。利用IBM SPSS Modeler 18.0、IBM SPSS Statistics 25.0、Cytoscape 3.10.0对组方用药进行用药频数及性味归经统计、关联规则分析、复杂网络可视化、聚类分析以及因子分析等。结果：共纳入中药复方219首，涉及225味中药。高频药物有黄芪、甘草、丹参、麦冬、当归等；功效以补虚、化痰止咳平喘、活血化瘀为主；药性以温、寒、平为主；药味以甘、苦、辛为主；归经以肺、肝、脾为主。关联规则分析共获得36组药对组合；系统聚类分析得到5个核心类方；因子分析共提取到9个公因子。结论：中药复方治疗肺纤维化遵循“扶正祛邪”的治疗原则，以扶正为本，辅以化痰、活血、清热等治法，多选择补虚药、化痰止咳平喘药、活血化瘀药、清热药等药物治疗。
关键词：肺纤维化；中药复方；数据挖掘；关联规则；聚类分析；因子分析
Abstract：
Objective: To explore the medication rules
of traditional Chinese medicine (TCM) compound prescriptions in the treatment
of pulmonary fibrosis. Methods: Clinical research literatures on TCM treatment
of pulmonary fibrosis included in China National Knowledge Infrastructure
(CNKI), Wanfang Data Knowledge Service Platform (Wanfang Data), China Science
and Technology Journal Database (CSTJ), and China Biomedical Literature Service
System (SinoMed) in the past decade were collected. After screening the
literatures according to the inclusion and exclusion criteria, Microsoft Excel
2021 was used to extract data and establish a database. IBM SPSS Modeler 18.0,
IBM SPSS Statistics 25.0, and Cytoscape 3.10.0 were applied to conduct
statistics on medication frequency, nature-flavor-meridian tropism, association
rule analysis, complex network visualization, cluster analysis, and factor
analysis of the prescriptions. Results:
A total of 219 TCM compound prescriptions were included, involving 225 kinds of
Chinese medicinal materials. The high-frequency medicinal materials included
Huangqi astragalus (Astragali Radix), Gancao (Glycyrrhizae Radix), Danshen
(Salviae Miltiorrhizae Radix), Maidong (Ophiopogonis Radix),Danggui (Angelicae
Sinensis Radix), etc. The main functions were tonifying deficiency, resolving
phlegm, relieving cough and asthma, and promoting blood circulation to remove
blood stasis. The natures of the medicinal materials were mainly warm, cold,
and neutral. The flavors were mainly sweet, bitter, and pungent. The meridian
tropisms were mainly related to the lung, liver, and spleen. A total of 36
pairs of medicinal combinations were obtained through association rule
analysis. 5 core formula categories were obtained through systematic cluster
analysis. 9 common factors were extracted through factor analysis. Conclusion:
TCM compound prescriptions in the treatment of pulmonary fibrosis follow the
treatment principle of "strengthening the healthy Qi and eliminating
pathogenic factors". Strengthening the healthy Qi is taken as the
foundation, supplemented by methods such as resolving phlegm, promoting blood
circulation, and clearing heat. Medicinal materials for tonifying deficiency,
resolving phlegm, relieving cough and asthma, promoting blood circulation to
remove blood stasis, and clearing heat are often selected for treatment.
Key words：pulmonary fibrosis; traditional Chinese medicine compound prescriptions; data mining; association rules; cluster analysis; factor analysis
发布时间：2026-01-08
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