基于核转录因子-κB信号通路探讨中医药治疗痛风性关节炎的研究进展*
作者：徐梦启1，张智辉1，杨德宝1，段 誉1，曹星星1，王俊发2，曹玉举1,2
单位：1.河南中医药大学骨伤学院，河南 郑州 450003； 2.河南中医药大学附属郑州中医骨伤病医院，河南 郑州 450048
引用：引用：徐梦启，张智辉，杨德宝，段誉，曹星星，王俊发，曹玉举.基于核转录因子-κB信号通路探讨中医药治疗痛风性关节炎的研究进展[J].中医药导报,2025,31(9):146-151.
DOI：10.13862/j.cn43-1446/r.2025.09.025
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摘要：痛风性关节炎（GA）是一种由嘌呤代谢紊乱和尿酸水平升高引起的代谢性疾病。核转录因子-κB（NF-κB）信号通路作为炎症反应的关键调控者，在GA的发病过程中起着重要作用。中医药治疗GA在临床中应用广泛且效果显著，越来越多研究显示，中药单体化合物（如黄酮类、酚类、生物碱等）以及中药复方（痛风汤、当归拈痛汤、桂枝白虎汤等）可多途径、多靶点和多效应抑制NF-κB信号通路传导，降低炎症因子水平，减轻关节肿胀及滑膜损伤，从而缓解GA发作。通过对中医药调控NF-κB信号通路治疗GA的相关文献进行综述，以期为GA的临床治疗提供新的思路和方法。
关键词：痛风性关节炎；核转录因子-κB信号通路；中医药；炎症反应；综述
Abstract：
Gouty arthritis (GA) is a metabolic disease
caused by purine metabolism disorder and elevated uric acid levels. The nuclear
transcription factor-kappa B (NF-κB) signaling pathway, as a key regulator of
inflammatory response, plays a crucial role in the pathogenesis of GA.
Traditional Chinese Medicine (TCM) is widely used and shows significant effects
in treating GA clinically. Growing research indicates that TCM monomeric
compounds (e.g., flavonoids, phenols, alkaloids) and compound prescriptions
[e.g., Tongfeng Decoction (痛风汤), Danggui Niantong Decoction (当归拈痛汤), Guizhi Baihu
Decoction (桂枝白虎汤)] can inhibit the NF-κB signaling pathway through multiple pathways, targets, and effects.
This inhibition reduces the levels of inflammatory factors, alleviates joint
swelling and synovial damage, thereby ameliorating GA attacks. This review
summarizes the literature on the regulation of the NF-κB signaling pathway by
TCM in the treatment of GA, aiming to provide new ideas and methods for its
clinical management.
Key words：gouty arthritis; nuclear factor-kappa B (NF-κB) signaling pathway; traditional Chinese medicine; inflammatory response; review
发布时间：2026-01-08
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