基于中西医临床病证特点的少弱精子症动物模型分析*

作者：景宇兰1，朱丛旭2，刘露梅2，何清湖2,3

单位：1.湖南中医药大学中医学院，湖南 长沙 410208； 2.湖南中医药大学中西医结合学院，湖南 长沙 410208； 3.湖南医药学院中医学院，湖南 怀化 418000

引用：引用：景宇兰，朱丛旭，刘露梅，何清湖.基于中西医临床病证特点的少弱精子症动物模型分析[J].中医药导报,2025,31(9):139-145.

DOI：10.13862/j.cn43-1446/r.2025.09.024

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摘要：

对少弱精子症的动物模型相关文献进行总结，同时基于少弱精子症的中西医临床诊断标准，对现有的少弱精子症动物模型进行分析研究。发现少弱精子症常用的造模方法有化学诱导法、物理诱导法、高脂饮食法与基因敲除法等，多由西医理论指导，其发病机制多与西医致病机制相符，与中医证型尚存在一定差异。因此，建议模型制备过程中施加中医干预因素，进一步制备符合中西医临床病证特点的少弱精子症动物模型，为今后中医药资源的合理应用与传承创新提供研究基础与证据支持。

关键词：少弱精子症；动物模型；中西医结合；吻合度

Abstract：

This study summarizes the literature on animal models of oligoasthenospermia and analyzes existing models based on the clinical diagnostic criteria of both Western medicine and Traditional Chinese Medicine (TCM) for this condition. Commonly used modeling methods for oligoasthenospermia include chemical induction, physical induction, high-fat diet feeding, and gene knockout. These methods are predominantly guided by Western medical theories, and their pathological mechanisms largely align with Western medical etiologies but still exhibit certain discrepancies from TCM syndrome types. Therefore, it is recommended to incorporate TCM intervention factors during the model preparation process to further develop animal models of oligoasthenospermia that better reflect the integrated clinical disease and syndrome characteristics of both TCM and Western medicine. This approach would provide a research foundation and evidence support for the rational application, inheritance, and innovation of TCM resources.

Key words：oligoasthenospermia; animal models; integrated traditional Chinese and Western medicine; degree of matching (with clinical features)

发布时间：2026-01-08

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