诊治癌因性疲乏的中西医研究进展*

作者：秦欢欢1，王江保1，屈建敏1，张 杨2，李彩霞2，王 刚2

单位：1.陕西中医药大学，陕西 咸阳 712046； 2.陕西中医药大学第二附属医院，陕西 咸阳 712000

引用：引用：秦欢欢，王江保，屈建敏，张杨，李彩霞，王刚.诊治癌因性疲乏的中西医研究进展[J].中医药导报,2025,31(9):131-138.

DOI：10.13862/j.cn43-1446/r.2025.09.023

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摘要：总结分析癌因性疲乏（CRF）的病因病机、发病机制、治疗方法方面的中西医文献，为临床研究提供借鉴。CRF是肿瘤患者常见的并发症，其病因与肿瘤自身、治疗方法、情绪认知等均有关。炎症因子失调、线粒体及肌肉功能失调、基因多态性等多种机制都与CRF发生发展相关联。Piper疲乏修订量表（PFS-R）、癌症治疗功能评估疲乏量表（FACT-F）等是诊断、评估CRF的重要依据，治疗时以非药物干预为主，辅之药物疗法。CRF属中医“虚劳”范畴，病性本虚标实，辨以气血阴阳亏虚为本，瘀、毒、痰、湿为标，将其分为不同证型加以介绍，并运用内治法、外治法及调护养生等措施。

关键词：癌因性疲乏；恶性肿瘤；虚劳；中西医；综述

Abstract：

This article aims to summarize and analyze the literature on the etiology, pathogenesis, and treatment of cancer-related fatigue (CRF) from both Traditional Chinese Medicine (TCM) and Western medicine perspectives, providing references for clinical research. CRF is a common complication in cancer patients, related to the tumor itself, treatment modalities, emotional and cognitive factors, among others. Mechanisms such as inflammatory cytokine dysregulation, mitochondrial and muscle dysfunction, and genetic polymorphisms are associated with the development and progression of CRF. Scales like PFS-R and FACT-F are essential for diagnosing and assessing CRF. Treatment primarily involves non-pharmacological interventions, supplemented by pharmacological therapy. In TCM, CRF falls under the category of "consumptive disease" (Xu Lao). Its nature is characterized by root deficiency (ben xu) and surface excess (biao shi), primarily identified as deficiency of qi, blood, yin, and yang as the root cause, with stasis, toxin, phlegm, and dampness as the manifesting symptoms. It is classified into different syndrome patterns and treated with internal therapies, external therapies, and lifestyle regulations.

Key words：cancer-related fatigue (CRF); malignant tumor; consumptive disease (Xu Lao); traditional Chinese and Western medicine; review

发布时间：2026-01-08

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