中医药干预轻度认知障碍的证据图谱分析*

作者：钟 琴1，徐义勇1，鲍梦婕1，高 娟2

单位：1.江西中医药大学护理学院，江西 南昌 330004； 2.江苏省中医院，江苏 南京 210029

引用：引用：钟琴，徐义勇，鲍梦婕，高娟.中医药干预轻度认知障碍的证据图谱分析[J].中医药导报,2025,31(8):184-190,223.

DOI：10.13862/j.cn43-1446/r.2025.08.029

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摘要：目的：评价中医药干预轻度认知障碍患者的相关研究证据。方法：检索中国知网、万方、维普、中国生物医学文献服务系统、PubMed、Web of Science、The Cochrane Library、EMbase的中医药干预轻度认知障碍患者的系统评价/Meta分析，使用AMSTAR 2量表评估文献质量，采用证据图谱可视化呈现干预措施、纳入研究样本量、方法学质量评价结果、研究结论分类等。结果：纳入41篇系统评价/Meta分析。其中，针刺治疗的干预措施占比较大，其次为中药；治法以益气补血、活血化瘀、祛痰开窍最常见。AMSTAR 2量表评价结果显示，纳入文献基金资助信息、排除文献清单及研究设计的选择等条目阐述较差。证据图谱显示，纳入文献中27篇结论为有益，14篇为可能有益。结论：中医药在干预轻度认知障碍方面具有一定的治疗效果，但本次纳入研究的文献在方法学质量上普遍偏低，未来迫切需要开展质量更高的相关研究，为中医药干预轻度认知障碍患者提供可靠的循证参考依据。

关键词：轻度认知障碍；证据图谱；中医药；AMSTAR 2量表

Abstract：

Objective: To evaluate the research evidence related to traditional Chinese medicine (TCM) intervention in patients with mild cognitive impairment (MCI). Methods: A systematic reviews/Meta-analyses on TCM intervention in MCI patients were retrieved from CNKI, Wanfang Database, VIP Database, SinoMed, PubMed, Web of Science, The Cochrane Library, and EMbase. The AMSTAR 2 scale was used to assess the quality of the literature, and evidence mapping was applied to visually present intervention measures, sample sizes of included studies, methodological quality evaluation results, and classification of research conclusions. Results: A total of 41 systematic reviews/Meta-analyses were included. Among them, acupuncture accounted for a large proportion of intervention measures, followed by Chinese herbal medicine. The most common therapeutic methods were replenishing Qi and blood, promoting blood circulation to remove stasis, and resolving phlegm to open the orifices. The results of the AMSTAR 2 scale evaluation showed that the included literature had poor elaboration on items such as funder information, excluded literature lists, and selection of study designs. Evidence mapping indicated that 27 of the included articles concluded that TCM interventions were beneficial, and 14 concluded they were possibly beneficial. Conclusion: TCM has certain therapeutic effects in intervening in mild cognitive impairment, but the methodological quality of the included studies in this analysis is generally low. There is an urgent need to conduct higher-quality studies in the future to provide reliable evidence-based references for TCM intervention in patients with mild cognitive impairment.

Key words：mild cognitive impairment; evidence mapping; traditional Chinese medicine; AMSTAR 2 scale

发布时间：2026-01-06

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