针灸治疗帕金森病作用机制的研究进展*
作者：张家瑞1，陆 瑾2，王 玥2，丁星浩3，梅鑫彤1，陈鑫炜1
单位：1.南京中医药大学，江苏 南京 210029； 2.南京中医药大学附属南京中医院，江苏 南京 210022； 3.南京靖安社区卫生服务中心，江苏 南京 210046
引用：引用：张家瑞，陆瑾，王玥，丁星浩，梅鑫彤，陈鑫炜.针灸治疗帕金森病作用机制的研究进展[J].中医药导报,2025,31(6):150-153,174.
DOI：10.13862/j.cn43-1446/r.2025.06.026
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摘要：
通过文献阅读与整理，阐述了针灸治疗帕金森病的作用机制及相关信号通路研究进展。帕金森病的中医病机与人体年老体虚、情志失调、体弱久病导致气血津液运化失常，脏腑功能紊乱，肝风、痰浊、虚风等扰动筋脉有关。针灸治疗帕金森病的作用机制与调节相关神经递质及蛋白、抗氧化应激、抑制神经炎症反应、调控神经元细胞凋亡有关。针刺可通过调节核因子红细胞系2相关因子2（Nrf2）/抗氧化反应元件（ARE）/NOD样受体热蛋白结构域相关蛋白3（NLRP3）/半胱氨酸天冬氨酸蛋白酶-1（Caspase-1）、脑源性神经营养因子（BDNF）/酪氨酸激酶受体B（TrkB）/环磷酸腺苷反应原件结合蛋白（CREB）、Toll样受体4（TLR4）/核因子κB（NF-κB）、Wnt/β-连环蛋白（β-catenin）、音猬因子（Shh） /补缀同源物1（Ptch1）信号通路治疗帕金森病。
关键词：针灸；帕金森病；作用机制；信号通路；综述
Abstract：
Through literature review and analysis,
this article elucidates the mechanisms and related signaling pathways of
acupuncture in treating Parkinson's disease (PD). In Traditional Chinese Medicine
(TCM) theory, the pathogenesis of PD is associated with aging, emotional
disturbances, chronic illness, and constitutional weakness, which lead to
dysfunction in qi-blood-fluid metabolism, visceral disorders, and disturbances
of liver wind, phlegm-turbidity, and deficient wind affecting the sinews. The
therapeutic mechanisms of acupuncture for PD involve modulation of
neurotransmitters and proteins, antioxidation, inhibition of neuroinflammation,
and regulation of neuronal apoptosis. Acupuncture can treat PD by modulating
multiple signaling pathways, including: the nuclear factor erythroid 2-related
factor 2 (Nrf2)/antioxidant response element (ARE)/NOD-like receptor thermal
protein domain associated protein 3 (NLRP3)/caspase-1 pathway, the brain-derived
neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB)/cAMP response
element-binding protein (CREB) pathway, the Toll-like receptor 4 (TLR4)/nuclear
factor kappa B (NF-κB) pathway, the Wnt/β-catenin pathway, and the sonic
hedgehog (Shh)/patched 1 (Ptch1) pathway.
Key words：acupuncture; Parkinson's disease; mechanism; signaling pathway; review
发布时间：2026-01-04
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