电喷雾检测器与蒸发光散射检测器在中药分析中应用对比研究进展

作者：付 裕，孙彦敏，张妤琳，吴嫣艳，庞庆林

单位：江苏省食品药品监督检验研究院，江苏 南京 210000

引用：引用：付裕，孙彦敏，张妤琳，吴嫣艳，庞庆林.电喷雾检测器与蒸发光散射检测器在中药分析中应用对比研究进展[J].中医药导报,2025,31(6):146-149,169.

DOI：10.13862/j.cn43-1446/r.2025.06.025

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摘要：中药成分复杂，为实现化合物的纯化分离及新化合物的发现，分析检测方法需具备多样性。蒸发光散射检测器（ELSD）和电喷雾检测器（CAD）是质量型检测器，均适用于半挥发性或非挥发性物质的检测，可作为其他液相检测器的有力补充。虽然两者在中药分析领域中应用逐步广泛，在中药质量控制中也发挥着重要作用，但在中药分析领域中两者则存在一定的差异性。ELSD的应用更具广泛性，而CAD在重复性、灵敏度等方面更有优势。

关键词：电喷雾检测器；蒸发光散射检测器；中药分析；质量控制；综述

Abstract：

Traditional Chinese medicine (TCM) exhibits complex chemical compositions, necessitating diverse analytical methods to achieve compound purification, separation, and discovery of novel constituents. As mass-sensitive detectors, both the evaporative light scattering detector (ELSD) and charged aerosol detector (CAD) are suitable for semi-volatile or non-volatile compounds, serving as powerful complements to other liquid chromatography detectors. Although these two detectors have been increasingly applied in TCM analysis and play significant roles in quality control, notable differences exist between them in this field. ELSD demonstrates broader applicability, whereas CAD exhibits superior performance in reproducibility and sensitivity.

Key words：charged aerosol detector; evaporative light scattering detector; traditional Chinese medicine analysis; quality control; review

发布时间：2026-01-04

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