中药双向调控细胞凋亡防治类风湿关节炎的研究进展

作者：周元姣，梅文亚，姜苏华，邓婷，刘湘丹，刘笑蓉

单位：湖南中医药大学药学院，湖南 长沙 410208

引用：

DOI：10.13862/j.cn43-1446/r.20260313.001

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摘要：

总结了细胞凋亡在类风湿关节炎（RA）滑膜增生与骨破坏中的关键作用，重点阐述了新兴信号通路（cGAS/STING、YAP/TAZ、AMPK/mTOR/ULK-1等）及成纤维样滑膜细胞（FLS）、软骨细胞凋亡在 RA中的调控作用。系统梳理了近年来中药活性成分、中药复方及中成药通过双向调控FLS和软骨细胞凋亡，从而治疗RA的研究进展，旨在为中医药防治RA 及相关药物研发提供理论依据。

关键词：类风湿关节炎；中药；细胞凋亡；成纤维样滑膜细胞；软骨细胞；综述

Abstract：

This article summarizes the pivotal role of apoptosis in synovial hyperplasia and bone destruction in rheumatoid arthritis (RA), with a focus on the regulatory functions of emerging signaling pathways (cGAS/STING, YAP/TAZ, AMPK/mTOR/ULK-1, etc.) and the apoptosis of fibroblast-like synovial cells (FLS) and chondrocytes in RA. It systematically reviews recent research progress on the therapeutic effects of active components in traditional Chinese medicine (TCM), TCM compound prescriptions, and Chinese patent medicines in treating RA by bidirectionally regulating FLS and chondrocyte apoptosis. The aim is to provide a theoretical basis for the prevention and treatment of RA with TCM and the development of related drugs.

Key words：rheumatoid arthritis; traditional Chinese medicine; apoptosis; fibroblast-like synovial cells; chondrocytes; review

发布时间：2026-03-13

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