中药调控PINK1/Parkin通路防治阿尔茨海默病的研究进展*

作者：颜新宇1，孙兴华2，张 淼2,3

单位：1.黑龙江中医药大学，黑龙江 哈尔滨 150040； 2.黑龙江中医药大学附属第二医院，黑龙江 哈尔滨 150001； 3.黑龙江省针药结合防治重大脑病重点实验室，黑龙江 哈尔滨 150040

引用：引用：颜新宇，孙兴华，张淼.中药调控PINK1/Parkin通路防治阿尔茨海默病的研究进展[J].中医药导报,2026,32(2):173-178.

DOI：10.13862/j.cn43-1446/r.2026.02.029

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摘要：线粒体自噬功能异常是阿尔茨海默病（AD）的主要发病机制之一，而PTEN诱导激酶1（PINK1）/帕金蛋白（Parkin）通路作为线粒体自噬的主要信号转导通路，在线粒体质量控制以及维持线粒体稳态中发挥至关重要的作用。近年来，研究发现细叶远志皂苷、β细辛醚等中药单体和黄芪散、开心散等中药复方均可通过干预PINK1/Parkin通路介导的线粒体自噬来防治AD。

关键词：阿尔茨海默病；PINK1/Parkin通路；中药；线粒体自噬；中药单体

Abstract：

Abnormal mitophagy function is one of the major pathogenesis of Alzheimer's disease (AD). As the main signal transduction pathway of mitophagy, the PTEN-induced kinase 1 (PINK1)/Parkin pathway plays a crucial role in mitochondrial quality control and maintenance of mitochondrial homeostasis. In recent years, studies have found that Chinese medicine monomers such as tenuifolin and β-asarone, as well as Chinese medicine compound prescriptions such as Huangqi Powder (黄芪散) and Kaixin Powder (开心散), can prevent and treat AD by intervening in mitophagy mediated by the PINK1/Parkin pathway.

Key words：Alzheimer's disease; PINK1/Parkin pathway; Chinese medicine; mitophagy; Chinese medicine monomer

发布时间：2026-03-05

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