系统免疫炎症指数、全身炎症反应指数与糖尿病肾脏病湿浊证的相关性研究

作者：潘辰宇，庞淑妤，李春瑶，卢 瑶，柴子涵，王 芳，王 琳，孙卫卫

单位：北京中医药大学东直门医院，北京 100700

引用：引用：潘辰宇，庞淑妤，李春瑶，卢瑶，柴子涵，王芳，王琳，孙卫卫.系统免疫炎症指数、全身炎症反应指数与糖尿病肾脏病湿浊证的相关性研究[J].中医药导报,2026,32(1):119-123.

DOI：10.13862/j.cn43-1446/r.2026.01.020

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摘要：

目的:探讨系统免疫炎症指数（SII）、全身炎症反应指数（SIRI）与糖尿病肾脏病（DKD）湿浊证的相关性。方法:纳入237例DKD患者（湿浊证组132例与非湿浊证组105例），比较两组患者肾功能指标与血清SII、SIRI水平，并讨论湿浊证与SII、SIRI的相关性。结果：湿浊证组患者血尿酸、尿素氮、血肌酐、24 h尿蛋白定量、SII、SIRI高于非湿浊证组，肾小球滤过率（eGFR）低于非湿浊证组，差异均有统计学意义（P＜0.05）。SII水平和湿浊证发生率随糖尿病肾脏病分期进展呈上升趋势（P＜0.05）。SII、SIRI与尿素氮、血肌酐、24 h尿蛋白定量呈正相关，与eGFR呈负相关，且SIRI与血尿酸呈正相关（P＜0.05）。SII、SIRI的增加与湿浊证积分的升高呈正相关（P＜0.01）。结论：DKD湿浊证患者具有更严重的肾功能损伤，其SII、SIRI水平更高；SII、SIRI与肾功能损伤相关，较高的SII、SIRI与DKD严重程度呈正相关，提示其可能成为评估DKD病情进展的潜在标志物；SII、SIRI水平升高与湿浊证加重相关。

关键词：糖尿病肾脏病；湿浊证；系统免疫炎症指数；全身炎症反应指数

Abstract：

Objective: To investigate the correlation between the systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and damp-turbidity syndrome in patients with diabetic kidney disease (DKD). Methods: A total of 237 DKD patients were enrolled, comprising 132 with damp-turbidity syndrome and 105 without. Renal function indices and serum levels of SII and SIRI were compared between the two groups. The correlation between damp-turbidity syndrome and SII/SIRI levels was analyzed. Results: Compared to the non-damp-turbidity syndrome group, patients with damp-turbidity syndrome exhibited significantly higher levels of uric acid, blood urea nitrogen (BUN), serum creatinine, 24-hour urinary protein excretion (24 h UTP), SII, and SIRI, along with a lower estimated glomerular filtration rate (eGFR) (P<0.05). Both the incidence of damp-turbidity syndrome and SII levels showed a significant increasing trend with advancing DKD stages (P<0.05). SII and SIRI levels were positively correlated with BUN, serum creatinine, and 24 h UTP, and negatively correlated with eGFR. Additionally, SIRI was positively correlated with uric acid (P<0.05). Elevated SII and SIRI levels were positively correlated with higher damp-turbidity syndrome symptom scores (P<0.01). Conclusion: DKD patients with damp-turbidity syndrome exhibit more severe renal impairment and higher levels of SII and SIRI. SII and SIRI correlate with renal function deterioration, and higher levels of these indices are positively associated with DKD severity, suggesting their potential as markers for assessing DKD progression. Furthermore, elevated SII and SIRI levels are significantly correlated with the aggravation of damp-turbidity syndrome.

Key words：diabetic kidney disease; damp-turbidity syndrome; systemic immune-inflammation index; systemic inflammatory response index

发布时间：2026-01-30

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