中医药调控NF-κB信号通路治疗卵巢癌的研究进展*

作者：冷亚文1，王 宇2，吴效科2

单位：1.黑龙江中医药大学，黑龙江 哈尔滨 150400； 2.黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150400

引用：引用：冷亚文，王宇，吴效科.中医药调控NF-κB信号通路治疗卵巢癌的研究进展[J].中医药导报,2025,31(8):152-159.

DOI：10.13862/j.cn43-1446/r.2025.08.024

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摘要：

系统综述了核转录因子-κB（NF-κB）信号通路在卵巢癌发生、发展及治疗耐药中的作用，并重点探讨了中医药通过调控该通路治疗卵巢癌的潜在机制与应用前景。NF-κB通路的异常激活可促进卵巢癌细胞的免疫逃逸、增殖、侵袭、转移及化疗耐药，其机制涉及多条下游信号分子与炎症因子的调控。多项研究表明，多种中药单体（如黄酮类、苷类、萜类、生物碱等）及复方（如扶正解毒汤、桂枝茯苓胶囊等）可通过抑制NF-κB通路活化，影响相关靶基因表达，从而诱导癌细胞凋亡、抑制增殖与迁移、逆转EMT进程、调节肿瘤微免疫环境及化疗敏感性。NF-κB通路是中医药治疗卵巢癌的重要靶点，但其作用机制具有细胞类型特异性且存在通路交叉对话，当前研究仍以临床前实验为主，未来需推进更多临床试验并深入探索NF-κB与其他通路的交互作用，以推动中医药在卵巢癌精准治疗中的应用。

关键词：卵巢癌；核转录因子-κB信号通路；肿瘤免疫逃逸；肿瘤微环境；中医药

Abstract：

This article provides a systematic review of the role of the nuclear factor kappa B (NF-κB) signaling pathway in the pathogenesis, progression, and therapy resistance of ovarian cancer, with a focused discussion on the potential mechanisms and application prospects of Traditional Chinese Medicine (TCM) in treating ovarian cancer by modulating this pathway. It highlights that aberrant activation of the NF-κB pathway promotes immune evasion, proliferation, invasion, metastasis, and chemotherapy resistance in ovarian cancer cells, through mechanisms involving the regulation of multiple downstream signaling molecules and inflammatory factors. Numerous studies have demonstrated that various TCM monomeric compounds (such as flavonoids, glycosides, terpenoids, alkaloids, etc.) and compound formulations (e.g., Fuzheng Jiedu Decoction, Guizhi Fuling Capsule, etc.) can inhibit NF-κB pathway activation, affect the expression of related target genes, and thereby induce cancer cell apoptosis, suppress proliferation and migration, reverse the epithelial-mesenchymal transition (EMT) process, modulate the tumor immune microenvironment, and enhance chemotherapy sensitivity. The authors conclude that the NF-κB pathway serves as an important target for TCM in the treatment of ovarian cancer. However, its mechanisms exhibit cell-type specificity and involve crosstalk with other pathways. Current research remains largely preclinical, and future efforts should advance more clinical trials and further explore the interactions between NF-κB and other signaling pathways to promote the application of TCM in precision therapy for ovarian cancer.

Key words：ovarian cancer; nuclear factor-kappa B signaling pathway; tumor immune evasion; tumor microenvironment; traditional Chinese medicine

发布时间：2026-01-06

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