基于数据挖掘探讨王文革治疗骨折内固定术后非感染性发热的用药规律*
作者：吕武荣，陈顺德，黄 为，崔立生，钱 锋，宋海林，康海龙，沈 浮，王文革
单位：湖南医药学院附属永州市中医院，湖南 永州 425000
引用：引用：吕武荣，陈顺德，黄为，崔立生，钱锋，宋海林，康海龙，沈浮，王文革.基于数据挖掘探讨王文革治疗骨折内固定术后非感染性发热的用药规律[J].中医药导报,2025,31(7):158-163.
DOI：10.13862/j.cn43-1446/r.2025.07.027
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摘要：目的：基于数据挖掘技术研究王文革教授治疗骨折内固定术后非感染性发热的用药规律，为以后的用药提供依据。方法：纳入67例患者，均为骨折内固定术后非感染性发热患者，通过建立数据库，使其临床数据标准化。通过Excel、R语言（V4.1.3）、Origin 2022对临床数据进行中药频次、四气五味、药物归经、关联规则、系统聚类等统计，得出相关用药规律。结果：共得到67首方剂，总共含80味中药，用药总频数为1 384次，中药频数前5位是茯苓、甘草、白术、川芎、当归，中药类别以活血化瘀药、补虚药为主；性味以苦、甘味，温、平、寒性药为主，归脾、肝、胃经药物居多；关联规则分析得出核心组方为赤芍、红花、桃仁、茯苓、白术、当归、生地黄、川芎、黄芪、甘草；聚类分析得到5类组合。结论:王文革治疗骨折内固定术后非感染性发热的用药原则为“益气健脾、活血化瘀、清热解毒”。数据挖掘研究结果与王文革治疗骨折内固定术后非感染性发热的学术观点一致。
关键词：骨折内固定术；非感染性发热；数据挖掘；王文革；用药规律
Abstract：
Objective:
To study the medication rules of Professor WANG Wenge in the treatment of non-infectious fever after fracture internal
fixation surgery based on data mining technology, so as to provide basis for
future medication. Methods: A total of 67 patients with non-infectious fever
after fracture internal fixation surgery were included. The clinical data were
standardized by establishing a database. Through Excel, R language (v4.1.3) and
Origin 2022, the clinical data were statistically analyzed for the frequency of
Chinese medicine, four Qi and five flavors, drug meridian, association rules,
and systematic clustering, and the relevant medication rules were obtained.
Results: A total of 67 prescriptions were obtained, containing 80 kinds of
Chinese herbs in total, with a total medication frequency of 1,384 times. The
top 5 Chinese herbs in frequency were Fuling (Poria), Gancao (Glycyrrhizae
Radix), Baizhu (Atractylodis Macrocephalae Rhizoma), Chuanxiong (Chuanxiong
Rhizoma), and Danggui (Angelicae Sinensis Radix). The categories of Chinese
herbs were mainly blood-activating and stasis-removing herbs, as well as
tonifying herbs. The properties and flavors are mainly bitter and sweet
flavors, warm, neutral, and cold herbs, and herbs entering the spleen, liver,
and stomach meridians were predominant. Association rule analysis revealed that
the core formula consisted of Chishao (Paeoniae Radix Rubra), Honghua (Carthami
Flos), Taoren (Persicae Semen), Fuling (Poria), Baizhu (Atractylodis
Macrocephalae Rhizoma), Danggui (Angelicae Sinensis Radix), Shengdihuang
(Rehmanniae Radix Exsiccata seu Recens), Chuanxiong (Chuanxiong Rhizoma),
Huangqi (Astragali Radix), and Gancao (Glycyrrhizae Radix). Clustering analysis
obtained 5 combinations. Conclusion: WANG Wenge's medication principle for
treating non-infectious fever after fracture internal fixation surgery is "tonifying
Qi and strengthening the spleen, promoting blood circulation to remove blood
stasis, and clearing heat and detoxifying". The results of data mining are
consistent with WANG Wenge's academic views on treating non-infectious fever
after fracture internal fixation surgery.
Key words：fracture internal fixation surgery; non-infectious fever; data mining; WANG Wenge; medication rules
发布时间：2026-01-06
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