中医药靶向调控沉默信息调节因子3干预慢性心力衰竭的研究策略及思考*
作者：刘昭炎1，顾 宁2
单位：1.南京中医药大学，江苏 南京 210022； 2.南京中医药大学附属南京中医院，江苏 南京 210022
引用：引用：刘昭炎，顾宁.中医药靶向调控沉默信息调节因子3干预慢性心力衰竭的研究策略及思考[J].中医药导报,2025,31(6):154-158.
DOI：10.13862/j.cn43-1446/r.2025.06.027
PDF：
下载PDF
摘要：
慢性心力衰竭是各种心血管疾病终末期的临床综合征，有较高的住院率及病死率，严重影响患者生活质量和生命健康。沉默信息调节因子3（SIRT3）位于线粒体上，是主要的线粒体去乙酰化酶，在细胞代谢、脂质代谢和氧化应激等过程中均有十分重要的作用，SIRT3已成为治疗心衰的新作用靶点。聚焦中医药靶向调控SIRT3干预慢性心力衰竭的研究进展，发现已有诸多研究表明中药单体和复方可通过调节SIRT3影响心肌细胞代谢、氧化应激、凋亡等多种途径，从而干预心衰的发展过程及转归，但大多研究仅停留在实验研究层面，临床转化屈指可数。未来的研究应着力于SIRT3相关信号通路的机制诠释，针对中医经典名方、名医大家经验效方、院内制剂等，开展多中心、大样本、高质量的随机对照试验（RCT），为中医药干预慢性心力衰竭、优化临床方案提供科学依据。
关键词：慢性心力衰竭；沉默信息调节因子3；中药单体；中药复方；综述
Abstract：
Chronic heart failure (CHF), a clinical
syndrome in the end-stage of various cardiovascular diseases, is characterized
by high hospitalization and mortality rates, severely impairing patients'
quality of life and health. Silent information regulator 3 (SIRT3), a major
mitochondrial deacetylase localized in mitochondria, plays critical roles in
cellular metabolism, lipid metabolism, and oxidative stress. SIRT3 has emerged
as a novel therapeutic target for heart failure. This article reviews recent
advances in the targeted regulation of SIRT3 by traditional Chinese medicine
(TCM) for CHF intervention. Accumulated studies indicate that TCM monomers and
compound formulations can modulate SIRT3 to influence cardiomyocyte metabolism,
oxidative stress, apoptosis, and other pathways, thereby intervening in CHF
progression and prognosis. However, most findings remain at the experimental
stage, with limited clinical translation. Future research should focus on
elucidating SIRT3-related signaling mechanisms and conducting multicenter,
large-scale, high-quality randomized controlled trials (RCTs) on classical TCM
formulas, empirical prescriptions from renowned TCM practitioners, and
hospital-prepared formulations. These efforts will provide scientific evidence
for optimizing TCM-based clinical strategies against CHF.
Key words：chronic heart failure; silent information regulater 3; traditional Chinese medicine monomers; traditional Chinese medicine compound formulations; review
发布时间：2026-01-04
点击量：56