小续命汤中毒性中药药对配伍减毒增效的研究进展*
作者：杜园玉1，张喜武2，徐敬娅1，余英杰1，赵 曼1，赵炜明1
单位：1.黑龙江中医药大学，黑龙江 哈尔滨 150040； 2.黑龙江中医药大学中医药研究院，黑龙江 哈尔滨 150040
引用：引用：杜园玉，张喜武，徐敬娅，余英杰，赵曼，赵炜明.小续命汤中毒性中药药对配伍减毒增效的研究进展[J].中医药导报,2025,31(12):190-195.
DOI：10.13862/j.cn43-1446/r.2025.12.031
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摘要：小续命汤作为治疗中风经典方剂，因含附子、苦杏仁等毒性中药，临床应用受限。本文从化学成分变化、药理作用影响等方面综述附子与人参、麻黄、甘草以及苦杏仁与甘草、麻黄等毒性中药药对配伍减毒增效的研究进展。研究表明，上述药对可通过调控药物中毒性成分含量、干预药物代谢路径及发挥协同药理效应实现减毒增效。本文还进一步梳理了小续命汤在治疗缺血性脑卒中时上述药对的高频配伍比例，旨在为小续命汤在脑卒中及相关疾病临床治疗的合理运用，提供有力理论与科学支撑。
关键词：小续命汤；毒性中药；药对；减毒增效；配伍规律
Abstract：
As a classic prescription for treating stroke, Xiaoxuming Decoction has limited clinical application due to containing toxic Chinese medicinal materials such as Fuzi (Aconiti Radix Lateralis Preparata) and Kuxingren (Armeniacae Semen Amarum). This paper reviews the research progress on the compatibility of toxic Chinese medicinal pairs for attenuation of toxicity and enhancement of efficacy, including the pairs of Fuzi (Aconiti Radix Lateralis Preparata) combined with Renshen (Ginseng Radix et Rhizoma), Mahuang (Ephedrae Herba) and Gancao (Glycyrrhizae Radix et Rhizoma), as well as Kuxingren (Armeniacae Semen Amarum) combined with Gancao (Glycyrrhizae Radix et Rhizoma) and Mahuang (Ephedrae Herba), from the perspectives of changes in chemical components and impacts on pharmacological effects. This paper reviews the research progress on the compatibility of toxic Chinese medicinal pairs for attenuation of toxicity and enhancement of efficacy, including the pairs of Fuzi (Aconiti Radix Lateralis Preparata) combined with Renshen (Ginseng Radix et Rhizoma), Mahuang (Ephedrae Herba) and Gancao (Glycyrrhizae Radix et Rhizoma), as well as Kuxingren (Armeniacae Semen Amarum) combined with Gancao (Glycyrrhizae Radix et Rhizoma) and Mahuang (Ephedrae Herba), from the perspectives of changes in chemical components and impacts on pharmacological effects.
Key words：Xiaoxuming Decoction; toxic traditional Chinese medicine; medicinal pairs; toxicity attenuation and efficacy enhancement; compatibility rules
发布时间：2026-01-30
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