连翘化学成分及抗呼吸道病毒作用机制研究进展
作者：孙 玲1,2，孙 楠1，徐 攀1，马建新1
单位：1.连云港市立东方医院，江苏 连云港 222042； 2.南京中医药大学，江苏 南京 210023
引用：引用：孙玲，孙楠，徐攀，马建新.连翘化学成分及抗呼吸道病毒作用机制研究进展[J].中医药导报,2025,31(3):146-154.
DOI：10.13862/j.cn43-1446/r.2025.03.024
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摘要：连翘作为常用清热解毒类药物，具有清热解毒、消肿散结、疏散风热的功效，是治疗呼吸系统疾病的常用药材。通过查阅国内外文献，对连翘所含苯乙醇苷类、木质素类、酚酸类、挥发油类、黄酮类等主要化学成分进行整理归纳，并对连翘抗3种常见呼吸道病毒[合胞病毒（RSV）、流感病毒（IV）及新型冠状病毒（SARS-CoV-2）]的作用和作用机制进行总结。
关键词：连翘；化学成分；流感病毒；合胞病毒；新型冠状病毒；作用机制；综述
Abstract：
As a commonly used traditional Chinese
medicine for clearing heat and detoxifying, Lianqiao (Forsythiae Fructus) has
the effects of clearing heat and detoxifying, reducing swelling and dissipating
lumps, and dispelling wind-heat. It is a commonly used medicinal material for
the treatment of respiratory system diseases. By reviewing domestic and
international literature, this paper organizes and summarizes the main chemical
constituents of Lianqiao (Forsythiae Fructus), such as phenylethanoid
glycosides, lignans, phenolic acids, volatile oils, and flavonoids. It also summarizes
the effects and mechanisms of action of Lianqiao (Forsythiae Fructus) against
three common respiratory viruses: respiratory syncytial virus (RSV), influenza
virus (IV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Key words：Lianqiao (Forsythiae Fructus); chemical constituents; influenza virus; RSV; SARS-CoV-2; mechanism of action; review
发布时间：2025-12-15
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