基于数据挖掘分析孙占学治疗玫瑰痤疮的用药规律*

作者：魏盛豪1,2，孙占学3，刘茹楠1,2，陶晓华2

单位：1.北京中医药大学第三临床医学院，北京 100029； 2.北京中医药大学，北京 100029； 3.北京中医药大学第三附属医院，北京 100029

引用：引用：魏盛豪，孙占学，刘茹楠，陶晓华.基于数据挖掘分析孙占学治疗玫瑰痤疮的用药规律[J].中医药导报,2025,31(2):138-144.

DOI：10.13862/j.cn43-1446/r.2025.02.025

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摘要：目的：分析孙占学治疗玫瑰痤疮的用药规律。方法：利用北京中医药大学第三附属医院门诊医生工作站平台，收集2021年8月至2023年11月期间就诊于北京中医药大学第三附属医院皮肤科孙占学门诊的玫瑰痤疮患者的信息。根据纳入标准与排除标准筛选出有效病历255份，建立数据库，应用古今医案云平台对其证候特点、中药处方用药频数等进行数据分析。结果：纳入处方255份，包含211种药物，累计药物频数为5 648，用药频数前5位的药物依次为金银花、连翘、百部、侧柏叶、枳壳。功效多为清热解毒、清热凉血、疏散风热，药性多寒、微寒，药味以苦、甘、辛为主。关联规则分析得到13个药物组合，金银花-连翘为支持度最高的药对。聚类分析得到5类群组，包括4个处方组合及1味核心中药，复杂网络分析得到15味核心中药。中药与证候关联21条，涉及热毒蕴肤证、肺胃蕴热证、痰瘀互结证，主要包括金银花、连翘、蒲公英、天花粉、皂角刺等20味中药。结论：孙占学治疗玫瑰痤疮遵从整体观念，注重脏腑同调，遵循清泻肺胃、清热解毒、化痰散瘀、护正通腑四大治则，善用经方，寒温并用，阴阳平调，配伍灵活。

关键词：玫瑰痤疮；用药规律；回顾性分析；数据挖掘；古今医案云平台；辨证论治；临床用药；频数统计

Abstract：

Objective: To analyze the medication rules of SUN Zhanxue in the treatment of osacea. Methods: The outpatient doctor workstation platform of the Third Affiliated Hospital of Beijing University of Chinese Medicine was used to collect the information of rosacea patients who visited the outpatient clinic of SUN Zhanxue in the Department of Dermatology of the Third Affiliated Hospital of Beijing University of Chinese Medicine from August 2021 to November 2023. A total of 255 valid medical records were screened according to the inclusion and exclusion criteria, and a database was established. The Ancient and Modern Medical Case Cloud Platform was used to conduct data analysis on the syndrome characteristics, frequency of traditional Chinese medicine prescriptions, etc. Results: A total of 255 prescriptions were included, including 211 kinds of drugs, with a cumulative drug frequency of 5 648. The top5 drugs with the highest frequency of use were Jinyinhua (Lonicerae Flos), Lianqiao (Forsythiae Fructus), Baibu (Stemonae Radix), Cebaiye (Platycladi Cacumen) and Zhiqiao (Aurantii Fructus). The effects are mainly fo clear heat and detoxify, clear heat and cool blood, evacuate wind and heat. The medicinal properties are mostly cold, slightly cold, and the medicinal flavors are mainly bitter, sweet and pungent. 13 drug combinations were obtained from association rule analysis, and Jinyinhua (Lonicerae Flos) - Lianqiao (Forsythiae Fructus) was the most supportive drug pair. Cluster analysis yielded 5 groups, including 4 prescription combinations and 1 core Chinese medicine, and 15 core Chinese medicines were analyzed by complex network. There are 21 associations between traditional Chinese medicine and syndromes, involving heat and poison syndrome, lung and stomach heat accumulation syndrome, and phlegm and stasis mutual combination syndrome, mainly including 20 flavors of traditional Chinese medicine, such as Jinyinhua (Lonicerae Flos), Lianqiao (Forsythiae Fructus), Pugongying (Taraxaci Herba), Tianhuafen (Trichosanthis Radix) and Zaojiaoci (Gleditsiae Spina). Conclusion: SUN Zhanxue's treatment of rosacea follows the overall concept, emphasizing the harmony of viscera, and follows the four major principles of purging the lungs and stomach, clearing away heat and detoxifying, dissolving phlegm and dissipating stasis, and protecting the right and clear the intestines. He makes good use of traditional Chinese medicine formulas, combines cold and warm elements, balances Yin and Yang, and has flexible compatibility.

Key words：rosacea; medication rules; retrospective analysis; data miming; The Ancient and Modern Medical Case Cloud Platform; treatment based on syndrome differentiation; clinical medication; frequency counting

发布时间：2025-12-13

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