夏桑菊核桃灸凝胶眼贴的制备工艺研究*

作者：杨静琦，许保海，张 静，姜 洋，侍 方

单位：首都医科大学附属北京积水潭医院，北京 100035

引用：引用：杨静琦，许保海，张静，姜洋，侍方.夏桑菊核桃灸凝胶眼贴的制备工艺研究[J].中医药导报,2025,31(2):57-60,70.

DOI：10.13862/j.cn43-1446/r.2025.02.010

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摘要：目的：对夏桑菊核桃灸的灸粉进行剂型改良，将其改制为夏桑菊核桃灸凝胶眼贴，确定最佳制备工艺。方法：在物料用量考察单因素实验基础上，以综合感官、初黏力和持黏力为评价指标，采用L9(34)正交试验法优化聚丙烯酸钠（NP-700）、羧甲基纤维素钠（CMC-Na）、甘羟铝、酒石酸的用量。结果：优选出最佳物料处方为夏桑菊药粉1.500 g、NP-700 0.400 g、CMC-Na 0.400 g、甘羟铝0.015 g、甘油5.000 g、蒸馏水4.000 g、酒石酸0.020 g，最佳搅拌时间为30 min，最佳搅拌温度为20~40 ℃。结论：该制备工艺简便稳定可行，所制备的夏桑菊核桃灸凝胶眼贴性能良好，适合制剂开发生产。

关键词：夏桑菊；核桃灸；凝胶贴膏；基质优化；制备工艺；单因素实验；正交试验

Abstract：

Objective: To reform the dosage form of Xiasangju walnut moxibustion powder, change it into Xiasangju walnut moxibustion eye-cataplasm, and determine the best preparation process. Methods: Based on the single factor experiment of material usage inspection, the amount of sodium polyacrylate (NP-700), sodium carboxymethyl cellulose (CMC-Na), aluminum glycyrrhizinate and tartaric acid are optimized by L9(34) orthogonal experiment with comprehensive sensory, initial viscosity and viscosity as evaluation indexes. Results: The best prescription is Xiasangju medicine powder 1.500 g, NP-700 0.400 g, CMC-Na 0.400 g, aluminum glycyrrhizinate 0.015 g, glycerin 5.000 g, distilled water 4.000 g, and tartaric acid 0.020 g. The best stirring time is 30 min, and the best stirring temperature is 20～40 ℃. Conclusion: The preparation process is simple, stable and feasible. The prepared Xiasangju walnut moxibustion eye-cataplasm has good performance and it is suitable for the development and production of preparations.

Key words：Xiasangju; walnut moxibustion; cataplasm; matrix optimization; preparation process; single factor experiment; orthogonal experiment

发布时间：2025-12-07

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